Carry-Over Quality of Pre-acclimatization to Altitude Elicited by Intermittent Hypoxia: A Participant-Blinded, Randomized Controlled Trial on Antedated Acclimatization to Altitude

Molecular Mechanisms of Acclimatization to High Altitude Hypoxia: Role of Hypoxia Mimetic Cobalt Chloride

Analysis of High-Altitude De-Acclimatization Syndrome after Exposure to High Altitudes: A Cluster-Randomized Controlled Trial

The syndrome of high-altitude de-acclimatization commonly takes place after long-term exposure to high altitudes upon return to low altitudes. The syndrome severely affects the returnee's quality of life. However, little attention has been paid to careful characterization of the syndrome and their underlying mechanisms. Male subjects from Chongqing (n = 67, 180 m) and Kunming (n = 70, 1800 m) v...

Structural Modifications of the Brain in Acclimatization to High-Altitude

Adaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear. Using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) with fractional anisotropy (FA) calculation, we investigated 28 Han immigrant residents (17-22 yr) born and raised at HA of 2616-4200 m in ...

Controlled hyperventilation after training may accelerate altitude acclimatization.

To the Editor: On January 28, 2014, a group of 26 trekkers (aged 29 to 65 years), under the supervision of the authors, ascended one of the world’s highest mountains (Mt. Kilimanjaro, 5895 m) in 48 hours (Figure 1). While doing so, the group appears to have broken new medical ground, utilizing a new method to largely prevent, and as needed, reverse, symptoms of acute mountain sickness (AMS). Se...

Altitude preexposure recommendations for inducing acclimatization.

For many low-altitude (<1500 m) residents, their travel itineraries may cause them to ascend rapidly to high (>2400 m) altitudes without having the time to develop an adequate degree of altitude acclimatization. Prior to departing on these trips, low-altitude residents can induce some degree of altitude acclimatization by ascending to moderate (>1500 m) or high altitudes during either continuou...